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If > 5 years, the effective dose is 25—35 mg/kg/day PO, given in 3 divided doses. You see a patient with a serum sodium level of 122 mEq/L (N 135-145) and a serum osmolality of 255 mOsm/kg H2O (N 280-295). The prednisolone drops are tapered every 1–2 weeks depending on the degree of clinical improvement.

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